Thursday, November 17, 2005

The current high tech approach to vitamin A deficiency

Alfred Sommer is a professor at the Johns Hopkins Bloomberg School of Public Health, and was involved in discovering vitamin A’s importance in infectious disease. His CV reads:

"In a series of complex intervention trials Sommer conducted in Indonesia (1976-1980), he and his research team discovered that vitamin A deficiency was far more common than previously recognized, and that even mild vitamin A deficiency dramatically increases childhood mortality rates, primarily because this deficiency reduces resistance to infectious diseases such as measles and diarrhea. Parallel studies Sommer organized with colleagues in Africa demonstrated that most cases of measles-associated pediatric blindness were also related to low vitamin A levels.

To prove these observations definitively, Sommer and his colleagues ran a number of large-scale, community-based, randomized trials from 1983 through 1992 and demonstrated the link between even mild vitamin A deficiency and pediatric mortality.

Moving from science to practice, Sommer next showed that the debilitating consequences of vitamin A deficiency could be effectively, quickly, and cheaply treated with oral high-dose vitamin A supplementation, and treatment did not require a sterile injectable preparation. As a result, the World Development Report (World Bank) declared vitamin A supplementation one of the most cost-effective of all health interventions.

The latest research by Dr. Sommer and his colleagues has shown that supplementing women of childbearing age with vitamin A or beta-carotene can reduce maternal mortality by an average of 45 percent. These dramatic results are now being tested in a new, large, randomized, controlled, field trial in Bangladesh, where the potential benefits of simultaneous supplementation with other micronutrients (zinc, folate, iron, B-complex) are being determined.
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